Cart
sales@molnova.com
Flavokawain B
CAS No. 1775-97-9
Flavokawain B ( Flavokawain B; Flavokawain-B; FlavokawainB )
Catalog No. M12673 CAS No. 1775-97-9
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | In Stock |
|
| 10MG | 237 | In Stock |
|
| 25MG | 402 | In Stock |
|
| 50MG | 581 | In Stock |
|
| 100MG | 799 | In Stock |
|
| 500MG | 1611 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameFlavokawain B
-
NoteResearch use only, not for human use.
-
Brief DescriptionFlavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).
-
DescriptionFlavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression; induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities; also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.
-
SynonymsFlavokawain B; Flavokawain-B; FlavokawainB
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1775-97-9
-
Formula Weight284.31
-
Molecular FormulaC17H16O4
-
Purity>98% (HPLC)
-
SolubilityChloroform: Soluble Dichloromethane: SolubleEthyl Acetate: SolubleAcetone: SolubleDMSO: 38 mg/mL (133.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESO=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=CC=C2
-
Chemical Name2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Tang Y, et al. Int J Cancer. 2010 Oct 15;127(8):1758-68.
2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778.
3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9.
4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.
2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778.
3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9.
4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.
molnova catalog
related products
-
FR054
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.
-
ACBI1
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively.
-
TJ191
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
